Genotypic vs Phenotypic Risk Assessment for Melanoma
نویسندگان
چکیده
منابع مشابه
Phenotypic vs genotypic approaches to biodiversity, from conflict to alliance.
Taxonomy has traditionally been based on morphological characters. Such a "phenotypic taxonomy" has steadily been replaced by the advent of molecular approaches, culminating with the rapid sequencing of genetic barcodes. The convenience of barcoding and its relative ease has relegated "phenotypic taxonomy" to a historical status. The use of genetics is undeniably powerful. It has relatively few...
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BACKGROUND Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites. METHODS We developed a model that simulates the kinetic effect of genetic variants of the enzymes CYP1A1, CYP1B1, and COMT on the production of the main carcinogenic estrogen metabolite, 4-hydroxyestradiol (4-OH...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2021
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djab077